This issue offers an interdisciplinary perspective on technology adoption, pedagogy, and public health in local and global contexts. First, it examines the perceptions of accountants in Atacame regarding the integration of artificial intelligence, highlighting the need to strengthen digital competencies. Meanwhile, the proposal on digital content strategies in Santa Elena demonstrates how communicational differentiation enhances competitiveness in the real estate sector. In the field of education, the issue addresses the incorporation of the history of mathematics as a tool for humanizing teaching and analyzes strategies for integrating digital technologies into the classroom to optimize meaningful learning. Furthermore, an evaluation of a university outreach project in Esmeraldas validates the impact of technical training in welding on youth empowerment. Finally, a review of e-cigarette use warns of their serious multisystemic effects, rounding out an issue that links pedagogical innovation, community development, and social awareness.